Abstract
Mitral valve prolapse (MVP) and mitral annular disjunction (MAD) are associated with arrhythmic risk, yet their relative associations with cardiac morphology remain poorly characterised. We developed an automated nnU-Net pipeline to screen 60,895 UK Biobank participants for MVP and MAD, followed by expert adjudication of screen-positive cases (n=6,966), with a recall of 0.999, a positive predictive value (precision) of 0.705 and an F1 score of 0.827. Using the adjudicated cohort, we performed biventricular shape analysis across four phenotypic subgroups (MAD−/MVP−, MAD+/MVP−, MAD−/MVP+, MAD+/MVP+) at end-diastole and end-systole. MVP was the dominant driver of annular displacement; isolated MAD produced a structurally distinct annulus- localised inward pattern. Correction for the effects of height and age in a biventricular atlas (n=51,481) confirmed a statistically significant, independent geometric imprint of MVP (mean displacement of 0.40 mm, p<0.001). These findings demonstrate that automated screening combined with quantitative shape analysis can disentangle the morphological signatures of MVP and MAD at scale.
Links to Paper and Supplementary Materials
Main Paper (Open Access Version): https://papers.miccai.org/miccai-2026-sat/paper/STACOM2026_043.pdf
SharedIt Link: Not yet available
SpringerLink (DOI): Not yet available
Supplementary Material: Not Submitted
Link to Open Review
Open Review Page: https://openreview.net/profile?id=~Alistair_Young1
BibTex
@InProceedings{SanTug_Automated_MICCAISAT2026,
author = { Sanver, Tugba AND Nicholls, Hannah L. AND Mauger, Charlène A. AND Xu, Hao AND Petersen, Steffen E. AND Aung, Nay AND Masci, Pier-Giorgio AND Young, Alistair A.},
title = { { Automated Detection and Shape Analysis of Mitral Valve Prolapse and Annular Disjunction in the UK Biobank } },
booktitle = {Medical Image Computing and Computer Assisted Intervention -- MICCAI 2026 Workshops and Challenges},
year = {2026},
publisher = {Springer Nature Switzerland},
volume = {LNCS 17267},
month = {pending},
page = {pending}
}