Abstract
Brain network disruption is often seen in preclinical Alzheimer’s disease, but it is unclear whether network alterations precede atrophy. Using SuStaIn disease progression modeling on 1,699 ADNI participants, we show that in the Typical progression subtype, network alterations in integration or segregation precede atrophy in the amygdala and hippocampus, highlighting their potential as an early disease marker.
Links to Paper and Supplementary Materials
Main Paper (Open Access Version): https://papers.miccai.org/miccai-2026-sat/paper/MLCN_2026_032.pdf
SharedIt Link: Not yet available
SpringerLink (DOI): Not yet available
Supplementary Material: Not Submitted
Link to Open Review
Open Review Page: https://openreview.net/forum?id=y4TBUrJcTR
BibTex
@InProceedings{BerBai_Network_MICCAISAT2026,
author = { Berman, Bailey AND de Jonge, Sterre AND Kang, Wenjie AND van Haaften, Myrthe F. AND Vernooij, Meike W. AND Vinke, Elisabeth J. AND Bron, Esther E.},
title = { { Network Alterations Precede Atrophy in Alzheimer’s Disease Progression Subtypes } },
booktitle = {Medical Image Computing and Computer Assisted Intervention -- MICCAI 2026 Workshops and Challenges},
year = {2026},
publisher = {Springer Nature Switzerland},
volume = {LNCS 17255},
month = {pending},
page = {pending}
}