Abstract
Diffusion-weighted imaging (DWI) remains highly vulnerable to subject motion, particularly in time-efficient protocols and in motion-prone populations. While slice-to-volume registration (SVR) can mitigate inter-slice and inter-stack misalignment, diffusion MRI introduces additional complexity due to diffusion-direction–dependent contrast and the requirement to align dozens of measurements within a common reference frame, effectively yielding a 4D registration problem. Existing approaches rely primarily on sequential modeling or pairwise similarity and often degrade under sparse gradient sampling or severe motion.
We introduce GraphSVR, a q-space–aware graph-based framework for 4D SVR registration in DWI. GraphSVR represents slice groups as nodes in an acquisition-structured graph, with edges encoding temporal proximity, spatial slice geometry and diffusion encoding relationships. A graph neural network predicts globally consistent stack-wise rigid motion, optimized in a self-supervised, zero-shot manner using only an anatomical reference image, without requiring paired ground-truth motion.
We evaluate GraphSVR using both fully synthetic diffusion simulations and realistic recombination-based simulations from real acquisitions with controllable motion severity and gradient sparsity. Performance is quantified using grid error (mm) and rotation error relative to known ground-truth transforms. Under severe motion, GraphSVR reduces grid error and rotation error by 73\% compared to FSL eddy, the standard DWI motion-correction method, with the largest gains observed in sparse-direction regimes. These results demonstrate that explicitly modeling acquisition structure through graph-based reasoning improves robustness and global consistency in 4D DWI motion estimation.Code is available at \url{https://github.com/nogakertes/GraphSVR.git}.
Links to Paper and Supplementary Materials
Main Paper (Open Access Version): https://papers.miccai.org/miccai-2026-sat/paper/GRAIL_003.pdf
SharedIt Link: Not yet available
SpringerLink (DOI): Not yet available
Supplementary Material: Not Submitted
Link to Open Review
Open Review Page: https://openreview.net/forum?id=cWDiYBdoVU
BibTex
@InProceedings{KerNog_GraphSVR_MICCAISAT2026,
author = { Kertes, Noga AND Link Sourani, Daphna AND Bronstein, Alex M. AND Freiman, Moti},
title = { { GraphSVR: q-Space–Aware Graph-Based Slice-to-Volume Registration for Diffusion MRI } },
booktitle = {Medical Image Computing and Computer Assisted Intervention -- MICCAI 2026 Workshops and Challenges},
year = {2026},
publisher = {Springer Nature Switzerland},
volume = {LNCS 17278},
month = {pending},
page = {pending}
}